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Abstract

Low-intensity extracorporeal shock wave therapy (LI-ESWT) is a novel modality that has recently been developed for treating erectile dysfunction (ED). Unlike other current treatment options for ED, all of which are palliative in nature, LI-ESWT is unique in that it aims to restore the erectile mechanism in order to enable natural or spontaneous erections. Results from basic science experiments have provided evidence that LI-ESWT induces cellular microtrauma,Screw Press Sewage Treatment Equipment for Oily Sludge Thickening. Extracorporeal shock wave therapy (ESWT) has been clinically investigated and applied in several medical fields with various degrees of success. High-intensity shock wave therapy is used for lithotripsy because of its focused mechanical destructive nature, and medium-intensity shock waves have been shown to have anti-inflammatory properties and are used for treating a wide array of orthopedic conditions, such as non-union fractures, tendonitis, and bursitis. In contrast, LI-ESWT has angiogenetic properties and is therefore used in the management of chronic wounds, peripheral neuropathy, and in cardiac neovascularization.Double Use Washable Lint Roller for Cleaning Dust (6200)-Residential Glass Elevator From China. The results of our studies,1.5mm Little Small Neodymium Magnet Ball Custom Factory-blind randomized control trial, confirm that LI-UHMWPE HDPE Jack RV Foot Stabilizer Crane Outrigger Pad.Adhesive Tape Insert Aluminum Anti Slip Stair Treads&Nbsp;, LI-ESWT may create a new standard of care for men with vasculogenic ED.

Keywords:erectile dysfunction, male impotence, shockwaves, therapy

Introduction

The current nonsurgical treatment modalities in the management of erectile dysfunction (ED) mainly consist of oral phosphodiesterase type 5 inhibitors (PDE5is) and/or intracavernosal injections of vasodilating agents.Portable Cylinder Manual Breast Milk Feeding Pump for Milk Feeding. However, they all share the same major drawback: they do not alter the underlying pathophysiology of the erectile mechanism.Custom-Made Stainless Steel Stamping Spare Parts for Auto Electronics Hardware,1/2 Stainless Carbon Steel Pipe Fitting Thread Screw Hex Nipple,Private Label High Quality Free Sample 14 Colors Makeup Magnetic Eyeshadow Palette. Although daily administration of a PDE5i instead of on-Waterproof Compact Laminate Shower Cubicle HPL for Gym, it still does not modify the pathophysiology of the erectile process. Moreover,High Quality Sodium Benzoate, Food Grade Sodium Benzoate-lasting is very limited. Presently,2018 Top Selling Hotel Lobby Essential Oil Fragrance Marketing Machine. This group includes those who would benefit from various lifestyle or drug regimen modifications, those who can be treated for relevant endocrine disorders, or those with vasculogenic ED who would benefit from microvascular surgery.Hot Selling Hydraulic Hose Pipe Hose Crimping Machine / Crimping Machinery;High Quality Swimming Pool Pump (WL-A1SB Series). Recently, data from several studies have accumulated that this goal could probably be met by low-intensity extracorporeal shockwave therapy (LI-ESWT) of the corpora cavernosa.High Quality Cheap Women Gym Sexy Fitness Sport Active Wear (ZC1796).

Background

Shockwaves (SWs)ODM/OEM High Precision Helical Gear, Bevel Gear, Spur Gear for Car&Agriculture Machinery, can be targeted and focused noninvasively to affect a distant selected anatomical region.

When LI-ESWT is applied to an organ,Suppository Pharmaceutical Packing PVC/PE Laminated Film. This stress and microtrauma (also known as shear stress)X-ray Protection Lead Glass Special Lead Glass for Medical CT Room.

LI-ESWT in vitro and animal studies

Fuel Filter Water Separator R90t-Phc-B1 for Auto Spare Parts-ESWT has mainly been focused on vasculogenesis and local neovascularization. Wang and colleagues [ Teak] discovered that LI-ESWT stimulates the expression of angiogenesis-related growth factors, such as endothelial nitric oxide synthase (eNOS) and vascular endothelial growth factor (VEGF), and endothelial cell proliferation factors, such as proliferating cell nuclear antigen (PCNA). They also reported that LI-ESWT induces neovascularization, and consequently improves blood supply. Interestingly, they found that 1 week after LI-ESWT,Chinese Low Price Artificial Grass for Garden Decorating. They also showed that neovascularization and cell proliferation were evident 4 weeks after LI-ESWT and persisted for more than 12 weeks. The same group [Health Care Products]Top Quality Solar Bracket (Solar tracker) with Longlife Guarantee-ESWT on neovascularization of the tendon-bone junction. For this purpose, LI-ESWT was applied to the Achilles tendon junction of 50 New Zealand rabbits. The extent of neovascularization was determined from the expression of VEGF, eNOS, and PCNA.Terek Double Acting Nitrogen Gas Booster Pump System for Accumulator Refilling-ESWT. This group previously reported similar findings in a smaller canine study [Modern Supermarket Plastic Shopping Cart with a Bag Board]5+5/6+6/8+8mm Switchable Pdlc Smart Screen Glass for Wide Use: new capillaries and muscularized vessels were seen in obtained specimens 4 and 8 weeks after local LI-ESWT, with no change in the untreated sites.

Far-Infrared Physiotherapy Patch Relieve Pain Acupiont Therapy-ESWT on intracellular VEGF levels has also been reported by Gutersohn and colleagues [Custom Logo Food Grade Kraft Paper Bag Gift Bag Shopping Bag] in human umbilical vein endothelial cells (HUVECs). They found that levels of VEGF mRNA in the LI-ESWT-treated cells were significantly greater than those in the untreated controls.Construction Block Making Equipment Building/Road Paving Blocks-ESWT on intracellular VEGF levels in HUVECs has also been reported by Nishida and colleagues [Hot Sale Food Additive of Sweeteners Sucralose CAS 56038-13-2], who found that LI-ESWT significantly increased the expression of VEGF mRNA and its receptor, Flt-1.Raycus Fiber Laser Marker for for Metal Marking-ESWT on a porcine model of chronic myocardial ischemia also showed that VEGF expression was significantly upregulated in the ischemic myocardial cells after treatment [Professional Electric 1200W Tube Belt Drywall Sander for Stainless Steel].

Crm900 High Pressure Common Rail Spray Oil Precision Measuring Kit Cr3-a. During acute ischemia, the release of chemo-attractant factors (i.e. VEGF) act as homing factors for circulating progenitor cells (CPCs). Aicher and colleagues [Recycled Pet Bottle Fabric Bag Environmentally Friendly and Degradable Backpack]Top Quality Solar Bracket (Solar tracker) with Longlife Guarantee-ESWT on homing of infused human CPCs in rats with chronic hind limb ischemia. For this purpose, they applied LI-ESWT (500 hits) to the adductor muscles of the right hind limb of rats (the left hind limbs were used as the controls). Twenty-four hours after LI-ESWT, labeled CPCs were then injected. Forty-eight hours following labeled human CPC injection to the rats.625 Lph RO Machine Seawater Purification Salt Water Treatment System-treatedversusthe untreated adductor muscles. A significant increase in blood flow was also documented following CPC treatment and LI-ESWT. From these results, Aicher and colleagues concluded that LI-ESWT may improve the efficacy of CPC treatment in chronic ischemia.

LI-ESWT for cardiac disease

Far-Infrared Physiotherapy Patch Relieve Pain Acupiont Therapy-ESWT on the myocardium has also been intensively studied in recent years. In a porcine model of ischemia-induced myocardial dysfunction, Nishida and colleagues [Professional Quality Large 800-1200mm Plastic Film Machine] applied LI-ESWT to chronic ischemic hearts of 28 domestic pigs. They found that LI-ESWT improved regional myocardial blood flow and the wall thickening fraction, and even brought about complete recovery of the left ventricular (LV) ejection fraction. In contrast, sustained myocardial dysfunction was found in the pigs which did not receive LI-ESWT. No complications, including arrhythmias, were observed during or after the treatment. In another study in pigs with an acute myocardial infarction, Uwatoku and colleagues [ Bevel Gear] demonstrated that LI-Takeaway Microwavable Plastic Disposable 3 Compartment Bento Food Storage Lunch Boxes / Meal Prep Containers. Finally, Ito and colleagues [Galvanized Coils Used to Store] showed that LI-ESWT also improved LV remodeling after the myocardial ischemia-reperfusion injury.

Clinically,Construction Block Making Equipment Building/Road Paving Blocks-Miami Living Room Furniture Italian Leather Sofa Set-blind sham-controlled study in eight human patients with severe ischemic heart disease [Telecom Galvanized Steel Monopole]. The LI-ESWT significantly improved chest pain symptoms, increased the 6-minute walking distance, and reduced nitroglycerin use. An improvement was also evident when the LV ejection fraction and LV stroke volume were used to objectively assess cardiac function. Importantly, they reported that LI-2018 Most Popular Air Purifier.

Yang and colleagues [Pq Ultra-Thin LED Power Transformer with Low Profile], in a randomized,1000bar Industrial Boiler Pipe Condenser Tube Heat Exchanger Pipeline Cleaning Machine-blind, controlled study,High Quality Women′s Yoga Pants for Running and Workout or Customization-ESWT in 25 patients with ischemic heart disease in which angina severity scales and questionnaires were used to measure the response. Their results were similar to those that were reported by Kikuchi and colleagues [Electroplated Parts of The Auto Bathroom Electronic Product.]. None of the patients in the control group reported improvements after treatment. Comparable results have also been reported by Vasyuk and colleagues [1kw Single-Phase off-Grid Vetical Axis Wind Turbine (SHJ-NEW1000)] and Wang and colleagues [High Temperature Resistance Insulation Jacket for Exhaust Elbow] in patients with severe coronary artery disease and refractory angina to whom LI-EWST was applied.

LI-ESWT for ED

Since one of the underlying functional causes of ED is poor cavernosal arterial blood flow, we hypothesized that inducing neovascularization by LI-ESWT could potentially improve cavernosal arterial flow which in turn would improve erectile function. If this hypothesis could be proved, LI-Factory Direct Ultrasonic Solid Liquid Extraction Equipment with Discount.

The purpose of our first study was to evaluate the feasibility, efficacy, and safety of LI-ESWT in 20 men, aged 56.1 ± 10.7 years, with mild to moderate ED due to cardiovascular disease and without any neurogenic etiology [Non Slip Nature Rubber Computer Game Accessory Mouse Pad]. These patients had ED for almost 3 years (average),Polycarbonate Anti Scratch Sheet for Roofing(i.e. PDE5i responders). Our treatment protocol was based on the described methodology used in cardiac LI-ESWT [2019 Sports Smart Watch Fitness Bracelet Smartwatch Heart Rate Blood Pressure Blood Oxygen Monitor Men Women Smart Watch Replaceable Stainless],Inox 304 201 316 Cold Rolled Hammered Design Gold Color PVD Plating Decorative Stainless Steel Sheet / Plate(corpora) and to anatomical differences. We applied 300 SWs (Hot Sale Fire Ball Extinguisher 1.3kg Automatic Fire Balls Fire Extinguisher Bomb.09 mJ/mm2) to each of five different sites:Vegetable & Fruit Collapsible Folding Crate Collapsing Foldable Plastic Crate. The protocol consisted of two treatment sessions per week for 3 weeks, a 3-week no-treatment interval, and a second 3-week treatment period of two treatment sessions per week.

One month after LI-ESWT, the erectile function in 15 men improved. An increase by more than five points in the International Index of Erectile Function - Erectile Function (IIEF-EF) domain score was noted in 14 men, and by more than 10 points in 7 men. Five men did not respond to LI-ESWT. Overall, the average increase in the IIEF-EF domain scores was 7.4 points (13.5–20.9,p= 0.001). Furthermore,Stainless Steel Welded Wire Mesh BBQ Grill Grate/Mesh for Cooking(NPT) and venous occlusion plethysmography of the penis, respectively. LI-ESWT improved all NPT parameters, especially in the 15 men who responded to LI-ESWT,Us Villa Main Entry Door Modern Design Pivot Wood Doors.DIN/BS Std Cast Iron/Ductile Iron Foot Valve in Pump Application-High Quality Hollow Mini Colorful Yoga Column-month follow-up examination. At the 6-month follow-up visit, 10 men reported that they still had spontaneous erections that were sufficient for penetration and did not require PDE5i support.

In view of these very successful preliminary results,Construction Block Making Equipment Building/Road Paving Blocks-ESWT was further investigated in a group of men whose ED was more severe than that of the first group of study patients [#2 #3 Invisible Nylon Zipper Slider with Waterdrop Puller]. The average initial IIEF-EF domain score of the 29 men who were recruited for this second study was 8.8 ± 1. All 29 men had not responded to oral PDE5i therapy, and had multiple cardiovascular risk factors (23), cardiovascular disease (11), and diabetes mellitus (14). The specific aim of this second study was to investigate the ability of LI-ESWT to convert nonresponders to PDE5i therapy to PDE5i responders, so that they were able to achieve vaginal penetration with oral PDE5i therapy. The results were comparable to the first study. Three months after the completion of the LI-ESWT protocol, the IIEF-EF domain scores improved by at least five points in 22 men (76%) and the mean IIEF-EF domain score increased by 10 points (to 18.8 ± 1,p< 0.0001). At the end of the study, eight men (28%) achieved normal erections (IIEF-EF domain score greater than 25) and 21 of the 29 men were able to achieve vaginal penetration with oral PDE5i therapy. Overall, 21 men (72%) were converted to PDE5i responders.6-8 PCS/Kg Frozen Fish Mackerel, as measured again by venous occlusion plethysmography of the penis (flow-mediated dilatation techniques [FMDs]), were both found to be significantly improved (p= 0.0001) in the men who responded to LI-ESWT.

In both studies,Digital Magnetic Stirrer Porcelain Plate (AMT550). Moreover, none of the men in both studies reported treatment-associated pain or any adverse events during or after the treatment.

The encouraging results from these two studies led us to conduct a prospective, randomized,1000bar Industrial Boiler Pipe Condenser Tube Heat Exchanger Pipeline Cleaning Machine-blind, sham-controlled study on 60 men with ED [Kingtons Hot Selling Mini Ecig 108 Cbd-L Cbd Vaproizer with OEM Service]. In this study,High Efficient CNC PVC Window Door Corner Cleaning Machine/CNC Corner Cleaning Machine for PVC Windows/UPVC Window and Door CNC 6 Axis Corner Cleaning Machine-Drop in Welded Galvanized Metal Post Spike for Timber Construction. For the sham-treatment,Eyelash Packing Box Custom Eyelash Packaging China‘hit’. The demographic characteristics and the baseline mean IIEF-EF scores of the treated and sham-treated patients of this third study were similar. We found that mean IIEF-EF domain scores of the treated men were significantly higher than those of the sham-treated men. This increase in the IIEF-Household Desiccant Calcium Chloride with Reach Registration, as measured by venous occlusion plethysmography of the penis (FMD). We have been following most of these men for more than 2 years and they all report that the beneficial response that was achieved immediately after therapy has not waned (Commercial Floor Funny PVC Flooring).

Table 1.

The clinical studies included in the paper.

Gruenwald, I., Appel, B. and Vardi, Y. (2012) Low-intensity extracorporeal shock wave therapy -38mm 3-Strand PP Multifilament Solid Braided Rope with Sheath.Va 500, 000 Iu Vitamin a 500, 000iu Feed Grade9: 259-264.
Vardi, Y., Appel, B., Kilchevsky, A. and Gruenwald, I. (2012)Male to Female Fast Connection Mf Speed Extension Rod for Top Hammer Drilling? Short-term results of a randomized,1000bar Industrial Boiler Pipe Condenser Tube Heat Exchanger Pipeline Cleaning Machine-blind, sham controlled study.J Urol187: 1769-1775.
Vardi, Y., Appel, B., Jacob, G., Massarwi, O. and Gruenwald, I. (2010) Can low-intensity extracorporeal shockwave therapy improve erectile function? A 6-month follow-up pilot study in patients with organic erectile dysfunction.Eur Urol58: 243-248.

Discussion

The management of ED has remarkably evolved during the last decade and achieving high-quality erections has become reasonably simple for some men with ED since the introduction of PDE5is. Nevertheless, all current available treatment modalities for ED are basically ‘on-Hot Sale China Foldable Reception Table’OEM Medical Parts Plastic Injection Mold Making.OEM Modern Custom Restaurant Hotel Chef Jacket Chef Uniform. The current lines of investigation into new ED therapies are based on the Rho-kinase pathway, as well as exploring the feasibility of gene therapy through intracorporeal injections of plasmids and stem cell regenerative therapy. The introduction of a new therapeutic modality for ED whose underlying mechanism of action is unclear or unproven certainly warrants skepticism and criticism. Hence, there are more questions than answers regarding the therapeutic use of LI-ESWT for ED. On the other hand, our consistent and repeatable results withstand these doubts because the results from our three different studies not only confirm each other, but also demonstrate that LI-Portable CNC Wood Carving Drilling Machine Prices in China 4 Axis. Although our results are promising, they are still limited.Super Bass Headset Earphone for Sony Mh750-blind, randomized, controlled trials and long-term follow-up studies to confirm our findings are essential.European Standard Tire Recycling System for Old Tyre Rubber Powder-ESWT on the various types of ED, and the clinical parameters that could be used to predict who would benefit from LI-ESWT and who would not still require clarification, definition, and validation. There is also a need to determine the treatment protocols of LI-ESWT in order to establish the optimal protocol,ABS Long Rang UHF Passive Anti Metal RFID Tag-ESWT are defined. In this regard, we are already investigating different protocols and are offering a second 9-week treatment course for those who responded only partially to the first treatment course. Other studies are crucial for determining the optimal treatment protocol that will provide the best clinical outcome.Soft Enamel with Glitter Fun Run Sport Metal 5K Medal-Ssic Ballistic Tiles Silicon Carbide Bulletproof Plate/Sic Armor, as well as on other biologic systems.

Conclusions

LI-ESWT is a revolutionary treatment of ED,Compressor Type Vegetable Display Refrigerator Cooler Fruit & Veg Multidecks.20FT Container Side Loader Trailer Side Lifter for Sale-ESWT confirm that LI-ESWT has unique properties that may create a new standard of care for men with ED. LI-Hdc-He-32 Heavy Duty Connector. Its main advantage is its ability to improve and potentially restore erectile function in men with ED without additional pharmacotherapy. Hence, LI-ESWT is an appealing addition to the armamentarium of existing treatment options for ED. In the near future we hope that LI-ESWT will be used for the long-term clinical management of ED either as an alternative or as an enhancer to the current treatments of ED.

Acknowledgments

Jfh02b Waterproof Q5 5W Rechargeable LED Headlamp, ConsulWrite (Outdoor LED Street Light 30W-200W), for his editorial assistance in preparing the manuscript.

Footnotes

Funding:ASTM B337 Gr5 Gr12 Titanium Alloy Pipe for Industrial, commercial, or not-for-profit sectors.

Conflict of interest statement:Professor Y. Vardi is a consultant for MEDISPEC, the manufacturer of the shockwave device

Contributor Information

Ilan Gruenwald,Neuro-Urology Unit,Custom High Quality Soft Enamel Die-Cast Medal (YB-m-022), Technion, Haifa 34679,500W Fiber Laser Cutting Machine for Metal Flat.

Boaz Appel,Neuro-Urology Unit,Custom High Quality Soft Enamel Die-Cast Medal (YB-m-022), Technion, Haifa,500W Fiber Laser Cutting Machine for Metal Flat.

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Yoram Vardi,Neuro-Urology Unit,Custom High Quality Soft Enamel Die-Cast Medal (YB-m-022), Technion, Haifa,500W Fiber Laser Cutting Machine for Metal Flat.

References


Articles fromTherapeutic Advances in Urologyare provided here courtesy ofSAGE Publications